GM Events-GUS


beta-D-glucuronidase  (Escherichia coli)

Approved/deregulated GM Crop events at global level






Papaya 55-1/63-1 Ring spot virus resistance Cornell University USA, Canada
Sugar beet GTSB77 Glyphosate tolerance Novartis, Monsanto USA, Australia, Japan, Philippines
Soybean G94-1, G94-19 and G168 Modified oleic acid Dupont USA, Australia, Japan, Canda
Soybean W62 and W98 Basta tolerance Bayer USA
Plum C5 Pox virus resistance USDA USA
Cotton 15985 (BG II) Insect resistance Monsanto USA, EU, India and 10 others
Cotton LL Cotton25 x MON15985 Basta tolerance +

Insect resistance

Bayer Japan, Korea, Mexico
Cotton MON15985 x MON88913 Insect resistance + Glyphosate tolerance Monsanto Australia, Colombia, South Africa and 3 others

Biosafety of E. coli beta-glucuronidase (GUS) in plants.

Transgenic Res. 1998 May;7(3):157-63.

Gilissen LJ, Metz PL, Stiekema WJ, Nap JP.

Department of Molecular Biology, CPRO-DLO, Wageningen, The Netherlands.


The beta-glucuronidase (GUS) gene is to date the most frequently used reporter gene in plants. Marketing of crops containing this gene requires prior evaluation of their biosafety. To aid such evaluations of the GUS gene, irrespective of the plant into which the gene has been introduced, the ecological and toxicological aspects of the gene and gene product have been examined. GUS activity is found in many bacterial species, is common in all tissues of vertebrates and is also present in organisms of various invertebrate taxa. The transgenic GUS originates from the enterobacterial species Escherichia coli that is widespread in the vertebrate intestine, and in soil and water ecosystems. Any GUS activity added to the ecosystem through genetically modified plants will be of no or minor influence. Selective advantages to genetically modified plants that posses and express the E. coli GUS transgene are unlikely. No increase of weediness of E. coli GUS expressing crop plants, or wild relatives that might have received the transgene through outcrossing, is expected. Since E. coli GUS naturally occurs ubiquitously in the digestive tract of consumers, its presence in food and feed from genetically modified plants is unlikely to cause any harm. E. coli GUS in genetically modified plants and their products can be regarded as safe for the environment and consumers.



Author: polumetla

I am a plant molecular biologist and biotechnologist. I worked as Director of National Research Centre on Plant Biotechnology, New Delhi, India; Director, Institute of Biotechnology, Acharya N.G. Ranga Agricultural University, Hyderabad, India; and Director, ICAR-Indian Institute of Rice Research, Hyderabad, India.

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